You can set REGENAUTO to off but you going to get an annoying dialog box all the time. Help File "Inhibits regeneration of the drawing until you use the REGEN or REGENALL command, or set REGENAUTO to on.
If you perform an action that requires a regeneration and that action is irrevocable (such as thawing layers), AutoCAD displays Regen queued on the command line.
If you perform an action that requires a regeneration and that action is revocable, AutoCAD displays the following message:
About to regen-proceed?
If you choose OK, AutoCAD regenerates the drawing. If you choose Cancel, AutoCAD cancels the last action that you performed and does not regenerate the drawing."